Pair Name	Medicarpin, TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B33.1]	Myeloid leukemia		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Up-regulation	Expression	BID	hsa637
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP7	hsa840
	Up-regulation	Cleavage	CASP8	hsa841
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	CFLAR	hsa8837
	Up-regulation	Expression	CYCS	hsa54205
	Up-regulation	Expression	DDIT3	hsa1649
	Up-regulation	Expression	DIABLO	hsa56616
	Down-regulation	Expression	DIABLO	hsa56616
	Up-regulation	Phosphorylation	EIF2S1	hsa1965
	Up-regulation	Expression	HSPA5	hsa3309
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Up-regulation	Expression	TNFRSF10B	hsa8795
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	K-562	Blast phase chronic myelogenous leukemia	Homo sapiens (Human)	CVCL_0004
	LAMA-84	Chronic myelogenous leukemia	Homo sapiens (Human)	CVCL_0388
	U-937	Adult acute monocytic leukemia	Homo sapiens (Human)	CVCL_0007
	OCI-AML-3	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_1844
Result	Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway